abstract：:Recent studies showed that somatic cancer mutations target genes that are in specific signaling and cellular pathways. However, in each patient only a few of the pathway genes are mutated. Current approaches consider only existing pathways and ignore the topology of the pathways. For this reason, new efforts have been...

journal_title：Scientific reports

authors： Ajwad R,Domaratzki M,Liu Q,Feizi N,Hu P

更新日期：2021-01-12 00:00:00

abstract：:The antibiosis effect of gallic acid on Spodoptera litura F. (Lepidoptera: Noctuidae) and its parasitoid evaluated by feeding six days old larvae on artificial diet incorporated with different concentrations (5 ppm, 25 ppm, 125 ppm, 625 ppm, 3125 ppm) of the phenolic compound revealed higher concentration (LC50) of ga...

journal_title：Scientific reports

authors： Punia A,Chauhan NS,Singh D,Kesavan AK,Kaur S,Sohal SK

更新日期：2021-01-12 00:00:00

abstract：:We delineate the four principal surface plasmon polariton coupling and interaction mechanisms in subwavelength gratings, and demonstrate their significant roles in shaping the optical response of plasmonic gratings. Within the framework of width-graded metal-insulator-metal nano-gratings, electromagnetic field confine...

journal_title：Scientific reports

authors： Shayegannia M,Montazeri AO,Dixon K,Prinja R,Kazemi-Zanjani N,Kherani NP

更新日期：2021-01-12 00:00:00

abstract：:The purpose of the present study was to assess the differential intraocular pressure response (IOP) to dexamethasone (DEX) treatment at two dose levels (100 or 500 nM) in perfusion cultured Indian cadaveric eyes to investigate glucocorticoid (GC) responsiveness. In a human organ-cultured anterior segment (HOCAS) set-u...

journal_title：Scientific reports

authors： Haribalaganesh R,Gowri Priya C,Sharmila R,Krishnadas S,Muthukkaruppan V,Willoughby CE,Senthilkumari S

更新日期：2021-01-12 00:00:00

abstract：:Human epididymis protein 4 (HE4) has been used as a biomarker of endometrial cancer (EC) in clinical practice. However, there remains a lack of systemic research on the critical values of HE4 for diagnosing different clinical stages and pathological types of EC. This study investigated the accuracy of human epididymis...

journal_title：Scientific reports

authors： Liu J,Han L,Jiao Z

更新日期：2021-01-12 00:00:00

abstract：:Inbreeding can depress individuals' fitness traits and reduce population viability. However, studies that directly translate inbreeding depression on fitness traits into consequences for population viability, and further, into consequences for management choices, are lacking. Here, we estimated impacts of inbreeding d...

journal_title：Scientific reports

authors： Trask AE,Ferrie GM,Wang J,Newland S,Canessa S,Moehrenschlager A,Laut M,Duenas LB,Ewen JG

更新日期：2021-01-12 00:00:00

abstract：:Hair regenerative medicine has emerged as a promising approach for the treatment of severe hair loss. Recent advances in three-dimensional tissue engineering, such as formation of hair follicle germs (HFGs), have considerably improved hair regeneration after transplantation in animal models. Here, we proposed an appro...

journal_title：Scientific reports

authors： Kageyama T,Chun YS,Fukuda J

更新日期：2021-01-12 00:00:00

abstract：:This study aimed to determine the clinicopathological features of the subtypes of ampullary carcinoma (AC) to explore the indications for endoscopic papillectomy (EP) in early AC. Fifty-seven patients with AC who underwent curative resection were retrospectively reviewed. The 0/IA stages were significantly more common...

journal_title：Scientific reports

authors： Yamamoto K,Itoi T,Nagata N,Sofuni A,Tsuchiya T,Ishii K,Tanaka R,Tonozuka R,Honjo M,Mukai S,Asai Y,Matsunami Y,Yamaguchi H,Matsubayashi J,Joyama E,Nagakawa Y

更新日期：2021-01-12 00:00:00

abstract：:Macro- and micro-environmental factors modulate parasite loads in fish, determining parasitic abundances, diversity, and interaction dynamics. In this study, seasonal variations in larval ectoparasites on fish larvae in the northern Humboldt Current System (HCS) were evaluated using a delta-gamma generalized linear mo...

journal_title：Scientific reports

authors： Paredes LD,Landaeta MF,Molinet C,González MT

更新日期：2021-01-12 00:00:00

abstract：:The regulatory (neuro)peptide galanin and its three receptors (GAL1-3R) are involved in immunity and inflammation. Galanin alleviated inflammatory bowel disease (IBD) in rats. However, studies on the galanin receptors involved are lacking. We aimed to determine galanin receptor expression in IBD patients and to evalua...

journal_title：Scientific reports

authors： Brunner SM,Reichmann F,Leitner J,Wölfl S,Bereswill S,Farzi A,Schneider AM,Klieser E,Neureiter D,Emberger M,Heimesaat MM,Weghuber D,Lang R,Holzer P,Kofler B

更新日期：2021-01-12 00:00:00

abstract：:In this study we used the Illumina Infinium Methylation array to investigate in a cohort of matched archival human tissue samples (n = 32) from 14 individuals with soft tissue sarcomas if genome-wide methylation changes occur during metastatic and recurrent (Met/Rec) disease. A range of sarcoma types were selected for...

journal_title：Scientific reports

authors： Vargas AC,Gray LA,White CL,Maclean FM,Grimison P,Ardakani NM,Bonar F,Algar EM,Cheah AL,Russell P,Mahar A,Gill AJ

更新日期：2021-01-12 00:00:00

abstract：:Since 2001, hundreds of thousands of hours of underwater acoustic recordings have been made throughout the Southern Ocean south of 60° S. Detailed analysis of the occurrence of marine mammal sounds in these circumpolar recordings could provide novel insights into their ecology, but manual inspection of the entirety of...

journal_title：Scientific reports

authors： Miller BS,IWC-SORP\/SOOS Acoustic Trends Working Group.,Balcazar N,Nieukirk S,Leroy EC,Aulich M,Shabangu FW,Dziak RP,Lee WS,Hong JK

更新日期：2021-01-12 00:00:00

abstract：:We investigated the effects of different intraoperative eyeball fixation techniques (superior rectus muscle suture [MS] and traction suture at the corneal limbus [CS]), on intraocular pressure (IOP) and the incidence of ptosis after phacotrabeculectomy. Forty-one eyes with different glaucoma types which qualified for ...

journal_title：Scientific reports

authors： Konopińska J,Lisowski Ł,Mariak Z,Wojnar M,Obuchowska I,Rękas M

更新日期：2021-01-12 00:00:00

abstract：:The synthesis of a new series of Gd(III)-arylphosphonium complexes is described and the solution stability of selected compounds is reported. Their lipophilicity and uptake in human glial (SVG p12) and human glioblastoma multiforme (T98G) cell lines are presented. The in vitro cytotoxicity of all complexes was determi...

journal_title：Scientific reports

authors： Hall AJ,Robertson AG,Hill LR,Rendina LM

更新日期：2021-01-12 00:00:00

abstract：:Our study focused on quantifying the alterations of streamflow at a weir site due to the construction of a mini-hydropower plant in the Gurugoda Oya (Sri Lanka), and evaluating the spatial responses of benthic macroinvertebrates to altered flow regime. The HEC-HMS 3.5 model was applied to the Gurugoda Oya sub-catchmen...

journal_title：Scientific reports

authors： Munasinghe DSN,Najim MMM,Quadroni S,Musthafa MM

更新日期：2021-01-12 00:00:00

abstract：:Riemerella anatipestifer is a major pathogenic microorganism in poultry causing serositis with significant mortality. Serotype 1 and 2 were most pathogenic, prevalent, and liable over the world. In this study, the intracellular metabolites in R. anatipestifer strains RA-CH-1 (serotype 1) and RA-CH-2 (serotype 2) were ...

journal_title：Scientific reports

authors： Liu J,Cheng A,Wang M,Liu M,Zhu D,Yang Q,Wu Y,Jia R,Chen S,Zhao X,Zhang S,Huang J,Ou X,Mao S,Gao Q,Wen X,Zhang L,Liu Y,Yu Y,Tian B,Pan L,Ur Rehman M,Chen X

更新日期：2021-01-12 00:00:00

abstract：:The volcanic eruption of Santorini in the Bronze Age left detectable debris across the Mediterranean, serving as an anchor in time for the region, synchronizing chronologies of different sites. However, dating the eruption has been elusive for decades, as radiocarbon indicates a date about a century earlier than archa...

journal_title：Scientific reports

authors： Ehrlich Y,Regev L,Boaretto E

更新日期：2021-01-12 00:00:00

abstract：:Accurately segmenting foods from optical images is a challenging task, yet becoming possible with the help of recent advances in Deep Learning based solutions. Automated identification of food items opens up possibilities of useful applications like nutrition intake monitoring. Given large variations in food choices, ...

journal_title：Scientific reports

authors： Siemon MSN,Shihavuddin ASM,Ravn-Haren G

更新日期：2021-01-12 00:00:00

abstract：:Urbanization-driven landscape changes are harmful to many species. Negative effects can be mitigated through habitat preservation and restoration, but it is often difficult to prioritize these conservation actions. This is due, in part, to the scarcity of species response data, which limit the predictive accuracy of m...

journal_title：Scientific reports

authors： Ettinger AK,Buhle ER,Feist BE,Howe E,Spromberg JA,Scholz NL,Levin PS

更新日期：2021-01-12 00:00:00

abstract：:This study aims to identify patterns of surface heat fluxes, and corresponding surface ocean responses, associated with synoptic-scale atmospheric events and their modulation on seasonal time scales. In particular, northerly and southerly wind events associated with atmospheric disturbances were analyzed using high-te...

journal_title：Scientific reports

authors： Tomita H,Cronin MF,Ohishi S

更新日期：2021-01-11 00:00:00

abstract：:Animal behavior is highly structured. Yet, structured behavioral patterns-or "statistical ethograms"-are not immediately apparent from the full spatiotemporal data that behavioral scientists usually collect. Here, we introduce a framework to quantitatively characterize rodent behavior during spatial (e.g., maze) navig...

journal_title：Scientific reports

authors： Donnarumma F,Prevete R,Maisto D,Fuscone S,Irvine EM,van der Meer MAA,Kemere C,Pezzulo G

更新日期：2021-01-11 00:00:00

abstract：:Polypoidal choroidal vasculopathy (PCV) is a distinctive type of neovascular age-related macular degeneration prevalent in many Asian countries. However, there is still some controversy in how the subtypes of PCV are classified. This post-hoc study redefined the branching vascular network (BVN) and PCV subtypes throug...

journal_title：Scientific reports

authors： Yeung L,Lai CC,Chen SN,Cheng CK,Yang CM,Hsieh YT,Tsai A,Yang CH

更新日期：2021-01-11 00:00:00

abstract：:Joubert syndrome (JS) is an inherited ciliopathy characterized by a distinctive cerebellar and brain stem malformation which is known as the "molar tooth sign" on axial brain images, hypotonia, and developmental delay. Approximately 25-30% of patients with JS have kidney disease and many of them progress to end-stage ...

journal_title：Scientific reports

authors： Takagi Y,Miura K,Yabuuchi T,Kaneko N,Ishizuka K,Takei M,Yajima C,Ikeuchi Y,Kobayashi Y,Takizawa T,Hisano M,Tsurusaki Y,Matsumoto N,Hattori M

更新日期：2021-01-11 00:00:00

abstract：:Conifer wood is an exceptionally stiff and strong material when its cellulose microfibrils are well aligned. However, it is not well understood how the polymer components cellulose, hemicelluloses and lignin co-operate to resist tensile stress in wood. From X-ray scattering, neutron scattering and spectroscopic data, ...

journal_title：Scientific reports

authors： Thomas LH,Altaner CM,Forsyth VT,Mossou E,Kennedy CJ,Martel A,Jarvis MC

更新日期：2021-01-11 00:00:00

abstract：:Due to chromatic aberration, blue images are defocused when the eye is focused to the middle of the visible spectrum, yet we normally are not aware of chromatic blur. The eye suffers from monochromatic aberrations which degrade the optical quality of all images projected on the retina. The combination of monochromatic...

journal_title：Scientific reports

authors： Benedi-Garcia C,Vinas M,Dorronsoro C,Burns SA,Peli E,Marcos S

更新日期：2021-01-11 00:00:00

abstract：:Mayer-Rokitansky-Küster-Hauser (MRKH) syndrome is a rare disease, characterised by the aplasia of vagina and uterus in women with a 46,XX karyotype. Most cases are sporadic, but familial recurrence has also been described. Herein, we investigated an Italian cohort of 36 unrelated MRKH patients to explore the presence ...

journal_title：Scientific reports

authors： Pontecorvi P,Bernardini L,Capalbo A,Ceccarelli S,Megiorni F,Vescarelli E,Bottillo I,Preziosi N,Fabbretti M,Perniola G,Benedetti Panici P,Pizzuti A,Grammatico P,Marchese C

更新日期：2021-01-11 00:00:00

abstract：:There is a global concern about the effects of climate change driven shifts in species phenology on crop pests. Using geographically and temporally extensive data set of moth trap catches and temperatures across the cotton growing states of India, we predicted the phenology of cotton pink bollworm Pectinophora gossypi...

journal_title：Scientific reports

authors： Fand BB,Nagrare VS,Bal SK,Naik VCB,Naikwadi BV,Mahule DJ,Gokte-Narkhedkar N,Waghmare VN

更新日期：2021-01-11 00:00:00

abstract：:While considered an extracellular pathogen, Pseudomonas aeruginosa has been reported to be engulfed by macrophages in cellular and animal models. However, the role of macrophages in P. aeruginosa clearance in vivo remains poorly studied. The major outer membrane porin OprF has been recently shown to be involved in P. ...

journal_title：Scientific reports

authors： Moussouni M,Berry L,Sipka T,Nguyen-Chi M,Blanc-Potard AB

更新日期：2021-01-11 00:00:00

abstract：:Circular RNAs (circRNAs) are covalently closed circular non-coding RNAs. Due to their structure, circRNAs are more stable and have longer half-lives than linear RNAs making them good candidates for disease biomarkers. Despite the scientific relevance of these molecules, the study of circRNAs in non-model organisms is ...

journal_title：Scientific reports

authors： Varela-Martínez E,Corsi GI,Anthon C,Gorodkin J,Jugo BM

更新日期：2021-01-11 00:00:00

abstract：:Roots have important roles for plants to withstand adverse environmental conditions, including salt stress. Biostimulant application was shown to enhance plant resilience towards abiotic stresses. Here, we studied the effect of a tannin-based biostimulant on tomato (Solanum lycopersicum L.) grown under salt stress con...

journal_title：Scientific reports

authors： Campobenedetto C,Mannino G,Beekwilder J,Contartese V,Karlova R,Bertea CM

更新日期：2021-01-11 00:00:00

abstract：:The comet assay is an electrophoretic technique used to assess DNA damage, as a marker of genotoxicity and oxidative stress, in tissues and biological samples including peripheral blood mononuclear cells (PBMCs) and whole blood (WB). Although numerous studies are performed on stored samples, the impact of cryopreserva...

journal_title：Scientific reports

authors： Marino M,Gigliotti L,Møller P,Riso P,Porrini M,Del Bo C

更新日期：2021-01-11 00:00:00

abstract：:Myelin water imaging is a quantitative neuroimaging technique that provides the myelin water fraction (MWF), a metric highly specific to myelin content, and the intra-/extra-cellular T2 (IET2), which is related to water and iron content. We coupled high-resolution data from 100 adults with gold-standard methodology to...

journal_title：Scientific reports

authors： Dvorak AV,Swift-LaPointe T,Vavasour IM,Lee LE,Abel S,Russell-Schulz B,Graf C,Wurl A,Liu H,Laule C,Li DKB,Traboulsee A,Tam R,Boyd LA,MacKay AL,Kolind SH

更新日期：2021-01-11 00:00:00

abstract：:De novo mutations (DNMs), including germinal and postzygotic mutations (PZMs), are a strong source of causality for Autism Spectrum Disorder (ASD). However, the biological processes involved behind them remain unexplored. Our aim was to detect DNMs (germinal and PZMs) in a Spanish ASD cohort (360 trios) and to explore...

journal_title：Scientific reports

authors： Alonso-Gonzalez A,Calaza M,Amigo J,González-Peñas J,Martínez-Regueiro R,Fernández-Prieto M,Parellada M,Arango C,Rodriguez-Fontenla C,Carracedo A

更新日期：2021-01-11 00:00:00

abstract：:Worldwide variation in human stature and limb proportions is widely accepted to reflect thermal adaptation, but the contribution of population history to this variation is unknown. Furthermore, stature and relative lower limb length (LLL) show substantial plastic responses to environmental stressors, e.g., nutrition, ...

journal_title：Scientific reports

authors： Pomeroy E,Stock JT,Wells JCK

更新日期：2021-01-11 00:00:00

abstract：:In this work we study the entropy of the Gibbs state corresponding to a graph. The Gibbs state is obtained from the Laplacian, normalized Laplacian or adjacency matrices associated with a graph. We calculated the entropy of the Gibbs state for a few classes of graphs and studied their behavior with changing graph orde...

journal_title：Scientific reports

authors： Glos A,Krawiec A,Pawela Ł

更新日期：2021-01-11 00:00:00

abstract：:Acute Ischemic Stroke (AIS) in the young is increasing in prevalence and the largest subtype within this cohort is cryptogenic. To curb this trend, new ways of defining cryptogenic stroke and associated risk factors are needed. We aimed to gain insights into the presence or absence of cardiovascular risk factors in ca...

journal_title：Scientific reports

authors： Dardick JM,Flomenbaum D,Labovitz DL,Cheng N,Liberman AL,Esenwa C

更新日期：2021-01-11 00:00:00

abstract：:The structural and mechanical properties of tissue and the interplay between them play a critical role in tissue function. We introduce the optomechanogram, a combined quantitative and qualitative visualization of spatially co-registered measurements of the microstructural and micromechanical properties of any tissue....

journal_title：Scientific reports

authors： Lee W,Ostadi Moghaddam A,Shen S,Phillips H,McFarlin BL,Wagoner Johnson AJ,Toussaint KC Jr

更新日期：2021-01-11 00:00:00

abstract：:Establishing robust genome engineering methods in the malarial parasite, Plasmodium falciparum, has the potential to substantially improve the efficiency with which we gain understanding of this pathogen's biology to propel treatment and elimination efforts. Methods for manipulating gene expression and engineering the...

journal_title：Scientific reports

authors： Nasamu AS,Falla A,Pasaje CFA,Wall BA,Wagner JC,Ganesan SM,Goldfless SJ,Niles JC

更新日期：2021-01-11 00:00:00

abstract：:Although the association between visual acuity (VA) and vision-related quality of life (VRQoL) has been well reported in patients with type 2 diabetes mellitus (T2DM), little is known about how unilateral and bilateral VA affects daily performance in such patients. For this cross-sectional study, patients were recruit...

journal_title：Scientific reports

authors： Liao KM,Wu WC,Jang Y,Su FY,Tsai LT

更新日期：2021-01-11 00:00:00

abstract：:Live birth is the most important concern for assisted reproductive technology (ART) patients. Therefore, in the medical reproductive centre, obstetricians often need to answer the following question: "What are the chances that I will have a healthy baby after ART treatment?" To date, our obstetricians have no referenc...

journal_title：Scientific reports

authors： Gao H,Liu DE,Li Y,Wu X,Tan H

更新日期：2021-01-11 00:00:00